InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Man2b1

Summary

InnateDB Protein

IDBP-176838.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Man2b1

Protein Name

mannosidase 2, alpha B1

Synonyms

AW107687; LAMAN;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034121

InnateDB Gene

IDBG-176836 (Man2b1)

Protein Structure

UniProt Annotation

Function

Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004559	alpha-mannosidase activity
GO:0005537	mannose binding
GO:0008270	zinc ion binding
GO:0015923	mannosidase activity
GO:0030246	carbohydrate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006013	mannose metabolic process
GO:0007611	learning or memory

Cellular Component

GO:0005764

lysosome

Protein Structure and Domains

PDB ID

MGI:107286

InterPro

IPR000602 Glycoside hydrolase family 38, N-terminal domain
IPR011013 Galactose mutarotase-like domain
IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
IPR011682 Glycosyl hydrolase family 38, C-terminal
IPR015341 Glycoside hydrolase, family 38, central domain
IPR028995 Glycoside hydrolase, families 57/38, central domain

PFAM

PF01074
PF07748
PF09261

PRINTS

PIRSF

SMART

SM00872

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O09159