Version 5.4
Mus musculus Gene: Man2b1
Summary
InnateDB Gene IDBG-176836.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Man2b1
Gene Name mannosidase 2, alpha B1
Synonyms AW107687; LAMAN
Species Mus musculus
Ensembl Gene ENSMUSG00000005142
Encoded Proteins
IDBP-176838
mannosidase 2, alpha B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104774:
This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:85083269-85098739
Strand Forward strand
Band C3
Transcripts
ENSMUST00000034121 ENSMUSP00000034121
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004559 alpha-mannosidase activity
GO:0005537 mannose binding
GO:0008270 zinc ion binding
GO:0015923 mannosidase activity
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006013 mannose metabolic process
GO:0007611 learning or memory
Cellular Component
GO:0005764 lysosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104774
View Gene Order
ENSBTAG00000006241
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00511
Other glycan degradation pathway
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00511
Other glycan degradation pathway
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt O09159
TrEMBL
UniProt Splice Variant
Entrez Gene 17159
UniGene Mm.4219
RefSeq NM_010764 XM_006530749
OMIM
CCDS CCDS22494
HPRD
IMGT
MGI ID MGI:107286
MGI Symbol Man2b1
EMBL AF044174 AF044175 AF044176 AF044177 AF044178 AF044179 AF044180 AF044181 AF044182 AF044183 AF044184 AF044185 AF044186 AF044187 AF044188 AF044189 AF044190 AF044191 AF044192 AK004817 AK147928 BC005430 U29947 U87240
GenPept AAC09470 AAC53369 AAC78560 AAH05430 BAB23588 BAE28235
RNA Seq Atlas 17159

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca