InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mknk1

Summary

InnateDB Protein

IDBP-176849.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mknk1

Protein Name

MAP kinase-interacting serine/threonine kinase 1

Synonyms

2410048M24Rik; Mnk1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019677

InnateDB Gene

IDBG-176847 (Mknk1)

Protein Structure

UniProt Annotation

Function

May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7- methylguanosine-containing mRNA cap. {ECO:0000269PubMed:9155017}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitously expressed in all tissues examined, with high levels in skeletal muscle. {ECO:0000269PubMed:9155017}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006417	regulation of translation
GO:0006446	regulation of translational initiation
GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0009651	response to salt stress
GO:0018105	peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response (InnateDB)
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

MGI:894316

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt