InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chd1l

Summary

InnateDB Protein

IDBP-176884.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chd1l

Protein Name

chromodomain helicase DNA binding protein 1-like

Synonyms

4432404A22Rik; Alc1; Snf2p;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029730

InnateDB Gene

IDBG-176882 (Chd1l)

Protein Structure

UniProt Annotation

Function

DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATPase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006338	chromatin remodeling
GO:0006974	cellular response to DNA damage stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1915308

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR002589 Macro domain
IPR006935 Helicase/UvrB domain
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR021006 Histone deacetylase complex, subunit 2/3
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF01661
PF04851
PF00270
PF11496

PRINTS

PIRSF

SMART

SM00490
SM00506
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CXF7