InnateDB Protein
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IDBP-176932.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Il17re
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Protein Name
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interleukin 17 receptor E
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Synonyms
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AA589509; IL-17RE; Il25r;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000062103
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InnateDB Gene
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IDBG-176930 (Il17re)
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Protein Structure
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Function |
Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors. {ECO:0000269PubMed:16310341, ECO:0000269PubMed:21982598, ECO:0000269PubMed:21993849}.
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Subcellular Localization |
Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted {ECO:0000305}.Isoform 3: Secreted {ECO:0000305}.Isoform 4: Cytoplasm {ECO:0000305}.Isoform 5: Cytoplasm {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in mucosal tissues, including trachea, lung, kidney and stomach. Highly expressed in colon epithelial cells. Also expressed in testis. Low expression, if any, in heart, liver, spleen, or brain. Among CD4 T-helper cells, expressed at high levels in Th17 cells. {ECO:0000269PubMed:16310341, ECO:0000269PubMed:21982598, ECO:0000269PubMed:21993848, ECO:0000269PubMed:21993849}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1889371
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InterPro |
IPR013568
SEFIR
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PFAM |
PF08357
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BH06
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57890
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UniGene |
Mm.131781
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RefSeq |
NP_665825
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MGI ID |
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MGI Symbol |
Il17re
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OMIM |
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CCDS |
CCDS20420
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HPRD |
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IMGT |
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EMBL |
AF458068
AK046302
AK046713
AK078876
AK169498
BC026737
BC069861
DQ092339
DQ092340
DQ092341
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GenPept |
AAH26737
AAH69861
AAM77572
AAZ85958
AAZ85959
AAZ85960
BAC32678
BAC32842
BAC37436
BAE41201
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