Version 5.4
Mus musculus Protein: Il17re
Summary
InnateDB Protein IDBP-176936.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il17re
Protein Name interleukin 17 receptor E
Synonyms AA589509; IL-17RE; Il25r;
Species Mus musculus
Ensembl Protein ENSMUSP00000054378
InnateDB Gene IDBG-176930 (Il17re)
Protein Structure
UniProt Annotation
Function Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors. {ECO:0000269PubMed:16310341, ECO:0000269PubMed:21982598, ECO:0000269PubMed:21993849}.
Subcellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted {ECO:0000305}.Isoform 3: Secreted {ECO:0000305}.Isoform 4: Cytoplasm {ECO:0000305}.Isoform 5: Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Predominantly expressed in mucosal tissues, including trachea, lung, kidney and stomach. Highly expressed in colon epithelial cells. Also expressed in testis. Low expression, if any, in heart, liver, spleen, or brain. Among CD4 T-helper cells, expressed at high levels in Th17 cells. {ECO:0000269PubMed:16310341, ECO:0000269PubMed:21982598, ECO:0000269PubMed:21993848, ECO:0000269PubMed:21993849}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006954 inflammatory response
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1889371
InterPro IPR013568 SEFIR
PFAM PF08357
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BH06
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 57890
UniGene Mm.131781
RefSeq NP_001029201
MGI ID
MGI Symbol Il17re
OMIM
CCDS CCDS20421
HPRD
IMGT
EMBL AF458068 AK046302 AK046713 AK078876 AK169498 BC026737 BC069861 DQ092339 DQ092340 DQ092341
GenPept AAH26737 AAH69861 AAM77572 AAZ85958 AAZ85959 AAZ85960 BAC32678 BAC32842 BAC37436 BAE41201

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca