InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vps35

Summary

InnateDB Protein

IDBP-177015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vps35

Protein Name

vacuolar protein sorting 35

Synonyms

AI647796; Mem3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034131

InnateDB Gene

IDBG-177013 (Vps35)

Protein Structure

UniProt Annotation

Function

Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in fat tissue, testis, brain, kidney, thymus, liver and pancreas, and at lower levels in heart, intestine and skeletal muscle. Detected in oocytes, pre-implantation embryos and at E6.5-E12.5.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006624	vacuolar protein processing
GO:0015031	protein transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005829	cytosol
GO:0016021	integral component of membrane
GO:0030904	retromer complex
GO:0070062	extracellular vesicular exosome