InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dcx

Summary

InnateDB Protein

IDBP-177033.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dcx

Protein Name

doublecortin

Synonyms

Dbct;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033642

InnateDB Gene

IDBG-177031 (Dcx)

Protein Structure

UniProt Annotation

Function

Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May participate along with PAFAH1B1/LIS-1 in a distinct overlapping signaling pathway that promotes neuronal migration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Cell projection {ECO:0000250}. Note=Localizes at neurite tips. {ECO:0000250}.

Disease Associations

Tissue Specificity

In neonatal tissues, highly expressed in brain, but not expressed in heart, liver, kidney and spleen. In adult tissues, faintly expressed in brain but not expressed in muscle, heart, lung, liver, spleen, intestine, kidney, testis and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0019901	protein kinase binding

Biological Process

GO:0001764	neuron migration
GO:0007420	brain development
GO:0021952	central nervous system projection neuron axonogenesis
GO:0035556	intracellular signal transduction
GO:0048675	axon extension
GO:0048813	dendrite morphogenesis