InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dcx

Summary

InnateDB Gene

IDBG-177031.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dcx

Gene Name

doublecortin

Synonyms

Dbct

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031285

Encoded Proteins

IDBP-177033

doublecortin

IDBP-177035

doublecortin

IDBP-255109

doublecortin

IDBP-255111

doublecortin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase. Studies in knockout mice lacking this gene and the LIS1 gene suggest that the molecular interaction of these two genes is important in both in neuronal migration and neurogenesis, and there is a cortical role of this gene in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. Multiple transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:143855842-143933311

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033642	ENSMUSP00000033642
ENSMUST00000087313	ENSMUSP00000084570
ENSMUST00000112856	ENSMUSP00000108477
ENSMUST00000112851	ENSMUSP00000108472
ENSMUST00000139920
ENSMUST00000125768

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0019901	protein kinase binding

Biological Process

GO:0001764	neuron migration
GO:0007420	brain development
GO:0021952	central nervous system projection neuron axonogenesis
GO:0035556	intracellular signal transduction
GO:0048675	axon extension
GO:0048813	dendrite morphogenesis

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0043005	neuron projection

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000077279

View Gene Order

ENSBTAG00000019591

Not yet available

Pathways

NETPATH

REACTOME

REACT_261444

Axon guidance pathway

REACT_219680

L1CAM interactions pathway

REACT_188576

Developmental Biology pathway

REACT_235102

Neurofascin interactions pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22312

Neurofascin interactions pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

lis1pathway

Lissencephaly gene (LIS1) in neuronal migration and development

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.12871 Mm.403731 Mm.408018

RefSeq

NM_001110222 NM_001110223 NM_001110224 NM_010025 XM_006528698

OMIM

CCDS

CCDS41157 CCDS53209 CCDS53210

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas