InnateDB Protein
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IDBP-177035.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dcx
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Protein Name
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doublecortin
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Synonyms
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Dbct;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000084570
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InnateDB Gene
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IDBG-177031 (Dcx)
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Protein Structure
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Function |
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May participate along with PAFAH1B1/LIS-1 in a distinct overlapping signaling pathway that promotes neuronal migration (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000305}. Cell projection {ECO:0000250}. Note=Localizes at neurite tips. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
In neonatal tissues, highly expressed in brain, but not expressed in heart, liver, kidney and spleen. In adult tissues, faintly expressed in brain but not expressed in muscle, heart, lung, liver, spleen, intestine, kidney, testis and placenta.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1277171
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InterPro |
IPR003533
Doublecortin domain
IPR017302
Neuronal migration protein doublecortin, chordata
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PFAM |
PF03607
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PRINTS |
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PIRSF |
PIRSF037870
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SMART |
SM00537
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TIGRFAMs |
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Modification |
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SwissProt |
O88809
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PhosphoSite |
PhosphoSite-O88809
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
13193
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UniGene |
Mm.408018
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RefSeq |
NP_001103692
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MGI ID |
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MGI Symbol |
Dcx
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OMIM |
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CCDS |
CCDS53209
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HPRD |
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IMGT |
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EMBL |
AB011678
AF045547
AY560329
BX530055
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GenPept |
AAC31799
AAT58219
BAA33387
CAM25089
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