InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pias4

Summary

InnateDB Protein

IDBP-177129.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pias4

Protein Name

protein inhibitor of activated STAT 4

Synonyms

Pias-gamma; Piasg; PIASY;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005064

InnateDB Gene

IDBG-177127 (Pias4)

Protein Structure

UniProt Annotation

Function

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, PML body {ECO:0000269PubMed:11731474, ECO:0000269PubMed:16816390}. Note=Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies. Accumulates in the cytoplasm upon treatment with UVB and TNF-alpha.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in testis. Also expressed in vascular endothelial cells, in primary keratinocytes and in the CNS, including cortex, olfactory bulb, spinal cord, thalamus and trigeminal ganglion. Low expression, if any, in liver and lung. {ECO:0000269PubMed:10854042, ECO:0000269PubMed:12750312}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007259	JAK-STAT cascade
GO:0007275	multicellular organismal development
GO:0016032	viral process
GO:0016055	Wnt signaling pathway
GO:0016925	protein sumoylation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033235	positive regulation of protein sumoylation
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:1902174	positive regulation of keratinocyte apoptotic process
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage