Version 5.4
Mus musculus Gene: Pias4
Summary
InnateDB Gene IDBG-177127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pias4
Gene Name protein inhibitor of activated STAT 4
Synonyms Pias-gamma; Piasg; PIASY
Species Mus musculus
Ensembl Gene ENSMUSG00000004934
Encoded Proteins
IDBP-177129
protein inhibitor of activated STAT 4
IDBP-536229
protein inhibitor of activated STAT 4
IDBP-538437
protein inhibitor of activated STAT 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21199872
Pias4 is a member of the Protein Inhibitor of Activated STAT protein family, which regulate innate immune response by controlling transcription induced by Tlr, Rlr and Jak/Stat signalling pathways. Pias4 specifically negatively regulate both Ifn transcription and Ifn stimulated gene expression through multiple mechanisms utilizing the function of different domains.
InnateDB Annotation from Orthologs
Summary
PMID 21199872
[Homo sapiens] PIAS4 is a member of the Protein Inhibitor of Activated STAT protein family, which regulate innate immune response by controlling transcription induced by TLR, RLR and JAK/STAT signalling pathways. PIAS4 specifically negatively regulate both IFN transcription and IFN stimulated gene expression through multiple mechanisms utilizing the function of different domains.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105229:
Gene Information
Type Protein coding
Genomic Location Chromosome 10:81153266-81167923
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000005064 ENSMUSP00000005064
ENSMUST00000134017
ENSMUST00000147436
ENSMUST00000146764 ENSMUSP00000122183
ENSMUST00000135765 ENSMUSP00000121361
ENSMUST00000129549
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 78 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019789 SUMO ligase activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007259 JAK-STAT cascade
GO:0007275 multicellular organismal development
GO:0016032 viral process
GO:0016055 Wnt signaling pathway
GO:0016925 protein sumoylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033235 positive regulation of protein sumoylation
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:1902174 positive regulation of keratinocyte apoptotic process
GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105229
View Gene Order
ENSBTAG00000000753
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
smad2_3pathway
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.34428
RefSeq NM_021501
OMIM
CCDS CCDS35992
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca