InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aif1

Summary

InnateDB Protein

IDBP-177228.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aif1

Protein Name

allograft inflammatory factor 1

Synonyms

AI607846; AIF-1; D17H6S50E; G1; Iba1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025257

InnateDB Gene

IDBG-177226 (Aif1)

Protein Structure

UniProt Annotation

Function

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. {ECO:0000269PubMed:10934045, ECO:0000269PubMed:11500035, ECO:0000269PubMed:11722645, ECO:0000269PubMed:11916959, ECO:0000269PubMed:14756805}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.

Disease Associations

Tissue Specificity

Abundantly expressed in the testis, moderately in the spleen and lymph nodes and at low levels in the liver and thymus. Detected in macrophages. {ECO:0000269PubMed:11722645}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0051015	actin filament binding

Biological Process

GO:0001774	microglial cell activation
GO:0001934	positive regulation of protein phosphorylation
GO:0006911	phagocytosis, engulfment
GO:0006954	inflammatory response
GO:0010629	negative regulation of gene expression
GO:0014739	positive regulation of muscle hyperplasia
GO:0016601	Rac protein signal transduction
GO:0030041	actin filament polymerization
GO:0030335	positive regulation of cell migration
GO:0031668	cellular response to extracellular stimulus
GO:0032870	cellular response to hormone stimulus
GO:0034097	response to cytokine
GO:0042102	positive regulation of T cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0048678	response to axon injury
GO:0051017	actin filament bundle assembly
GO:0051602	response to electrical stimulus
GO:0071315	cellular response to morphine
GO:0071346	cellular response to interferon-gamma
GO:0071447	cellular response to hydroperoxide
GO:0071672	negative regulation of smooth muscle cell chemotaxis
GO:0071673	positive regulation of smooth muscle cell chemotaxis
GO:0090026	positive regulation of monocyte chemotaxis
GO:0097178	ruffle assembly
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
GO:2000406	positive regulation of T cell migration

Cellular Component

GO:0001726	ruffle
GO:0001891	phagocytic cup
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005884	actin filament
GO:0030027	lamellipodium
GO:0032587	ruffle membrane
GO:0042995	cell projection
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm