Version 5.4
Mus musculus Protein: ENTPD4
Summary
InnateDB Protein IDBP-177231.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENTPD4
Protein Name ectonucleoside triphosphate diphosphohydrolase 4
Synonyms 1200014F22Rik; 4930513O14Rik; A430102M06Rik; AI414893; Lysal1; mKIAA0392;
Species Mus musculus
Ensembl Protein ENSMUSP00000065046
InnateDB Gene IDBG-703704 (ENTPD4)
Protein Structure
UniProt Annotation
Function Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes in the Golgi and autophagic vacuoles/lysosomes. {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:10858452}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0045134 uridine-diphosphatase activity
Biological Process
GO:0006256 UDP catabolic process
GO:0008152 metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0000421 autophagic vacuole membrane
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID MGI:1914714
InterPro IPR000407 Nucleoside phosphatase GDA1/CD39
PFAM PF01150
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DBT4
PhosphoSite PhosphoSite-
TrEMBL Q8R0U1
UniProt Splice Variant
Entrez Gene 67464
UniGene
RefSeq XP_003688977
MGI ID
MGI Symbol Entpd4
OMIM
CCDS CCDS27240
HPRD
IMGT
EMBL AC160639 AC214054 AK004761 AK031065 AK045342 BC006924 BC026420 BC043134
GenPept AAH06924 AAH26420 AAH43134 BAB23542 BAC27236 BAC32317

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca