InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Siglece

Summary

InnateDB Protein

IDBP-177260.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Siglece

Protein Name

sialic acid binding Ig-like lectin E

Synonyms

Cd170; mSiglec-E; Siglec12; Siglec5; Siglec9; Siglecl1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032667

InnateDB Gene

IDBG-177258 (Siglece)

Protein Structure

UniProt Annotation

Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed by monocytic/myeloid lineage cells. Found at higher levels in spleen, liver and heart. Found at lower levels in kidney and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0048029	monosaccharide binding