InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lta

Summary

InnateDB Protein

IDBP-177401.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lta

Protein Name

lymphotoxin A

Synonyms

hlb382; LT; LT-[a]; LT-alpha; LT[a]; LTalpha; Ltx; TNF-beta; Tnfb; TNFSF1; Tnfsf1b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025266

InnateDB Gene

IDBG-177399 (Lta)

Protein Structure

UniProt Annotation

Function

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

Subcellular Localization

Secreted {ECO:0000250}. Membrane {ECO:0000250}. Note=The homotrimer is secreted. The heterotrimer is membrane-associated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006927	transformed cell apoptotic process
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006959	humoral immune response
GO:0007584	response to nutrient
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0009987	cellular process
GO:0032496	response to lipopolysaccharide
GO:0032729	positive regulation of interferon-gamma production
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0044130	negative regulation of growth of symbiont in host
GO:0048147	negative regulation of fibroblast proliferation
GO:0048535	lymph node development
GO:0050830	defense response to Gram-positive bacterium
GO:0060252	positive regulation of glial cell proliferation