Version 5.4
Mus musculus Gene: Lta
Summary
InnateDB Gene IDBG-177399.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lta
Gene Name lymphotoxin A
Synonyms hlb382; LT; LT-[a]; LT-alpha; LT[a]; LTalpha; Ltx; TNF-beta; Tnfb; TNFSF1; Tnfsf1b
Species Mus musculus
Ensembl Gene ENSMUSG00000024402
Encoded Proteins
IDBP-177401
lymphotoxin A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000226979:
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin\'s lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35203165-35205351
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000025266 ENSMUSP00000025266
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006927 transformed cell apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0007584 response to nutrient
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0009987 cellular process
GO:0032496 response to lipopolysaccharide
GO:0032729 positive regulation of interferon-gamma production
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0044130 negative regulation of growth of symbiont in host
GO:0048147 negative regulation of fibroblast proliferation
GO:0048535 lymph node development
GO:0050830 defense response to Gram-positive bacterium
GO:0060252 positive regulation of glial cell proliferation
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000226979
View Gene Order
ENSBTAG00000000016
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04940
Type I diabetes mellitus pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04940
Type I diabetes mellitus pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
il4_2pathway
IL4-mediated signaling events
il2_stat5pathway
IL2 signaling events mediated by STAT5
Cross-References
SwissProt P09225
TrEMBL Q542S2
UniProt Splice Variant
Entrez Gene 16992
UniGene Mm.418612
RefSeq NM_010735 XM_006523731 XM_006525331 XM_006536550 XM_006537284
OMIM
CCDS CCDS28692
HPRD
IMGT
MGI ID MGI:104797
MGI Symbol Lta
EMBL AF109719 AK080308 AK153694 BC099464 M16819 M17015 M60586 U06950 X06217 X06218 X14800 Y00137 Y00467
GenPept AAA18593 AAA39450 AAA40460 AAA40461 AAC82485 AAH99464 BAC37874 BAE32147 CAA29566 CAA29567 CAA32906 CAA68330 CAA68529
RNA Seq Atlas 16992

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca