InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp5o

Summary

InnateDB Protein

IDBP-177433.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp5o

Protein Name

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

Synonyms

ATPO; D12Wsu28e; OSCP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023677

InnateDB Gene

IDBG-177431 (Atp5o)

Protein Structure

UniProt Annotation

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Subcellular Localization

Mitochondrion {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005496	steroid binding
GO:0032403	protein complex binding
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism

Biological Process

GO:0015986	ATP synthesis coupled proton transport
GO:0046034	ATP metabolic process

Cellular Component

GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
GO:0005739	mitochondrion
GO:0005753	mitochondrial proton-transporting ATP synthase complex