Version 5.4
Mus musculus Protein: Sec22b
Summary
InnateDB Protein IDBP-177496.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sec22b
Protein Name SEC22 vesicle trafficking protein homolog B (S. cerevisiae)
Synonyms 4930564D15Rik; AA517334; AI480645; C81333; ERS-24; Sec22l1;
Species Mus musculus
Ensembl Protein ENSMUSP00000029476
InnateDB Gene IDBG-177494 (Sec22b)
Protein Structure
UniProt Annotation
Function SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Melanosome {ECO:0000250}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005484 SNAP receptor activity
GO:0019905 syntaxin binding
Biological Process
GO:0006810 transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0048280 vesicle fusion with Golgi apparatus
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0031201 SNARE complex
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042470 melanosome
Protein Structure and Domains
PDB ID MGI:1338759
InterPro IPR001388 Synaptobrevin
IPR010908 Longin domain
IPR011012 Longin-like domain
PFAM PF00957
PF13774
PRINTS PR00219
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O08547
PhosphoSite PhosphoSite-O08547
TrEMBL
UniProt Splice Variant
Entrez Gene 20333
UniGene Mm.402040
RefSeq NP_035472
MGI ID 1IFQ
MGI Symbol Sec22b
OMIM
CCDS CCDS17658
HPRD
IMGT
EMBL AK017237 AK034973 AK037918 AK088514 AK089928 BC009024 U91538
GenPept AAC53130 AAH09024 BAB30646 BAC28899 BAC29901 BAC40397 BAC40999

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca