InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klk8

Summary

InnateDB Protein

IDBP-177521.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klk8

Protein Name

kallikrein related-peptidase 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082588

InnateDB Gene

IDBG-177519 (Klk8)

Protein Structure

UniProt Annotation

Function

Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. {ECO:0000269PubMed:10762375, ECO:0000269PubMed:11880192, ECO:0000269PubMed:12944500, ECO:0000269PubMed:16308352, ECO:0000269PubMed:16537644, ECO:0000269PubMed:17182622, ECO:0000269PubMed:17629414, ECO:0000269PubMed:9556608}.

Subcellular Localization

Secreted. Cytoplasm. Note=Shows a cytoplasmic distribution in the keratinocytes.

Disease Associations

Tissue Specificity

Expressed in the limbic system of mouse brain and is localized at highest concentration in pyramidal neurons of the hippocampal CA1-3 subfields. Also detected in spinal cord gray matter and in keratinized stratified epithelia of epidermis, hair, tongue, palate, nasal cavity, pharynges, esophagus and forestomach. In skin and mucus membranes, expressed in stratum spinosum and stratum granulosum. Expressed during estrus in vaginal epithelial cells but not stromal cells. Within the vaginal epithelium, expressed in prickle cells, granular cells and parakeratotic cells but not in basal cells. Not expressed in uterus. Expressed in the keratinocytes. {ECO:0000269PubMed:12354676, ECO:0000269PubMed:17629414, ECO:0000269PubMed:17761692, ECO:0000269PubMed:7623137, ECO:0000269PubMed:8602273, ECO:0000269PubMed:9620300, ECO:0000269PubMed:9749739}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0007613	memory
GO:0008219	cell death
GO:0009611	response to wounding
GO:0031642	negative regulation of myelination
GO:0043616	keratinocyte proliferation
GO:0048681	negative regulation of axon regeneration
GO:0048812	neuron projection morphogenesis
GO:0050807	regulation of synapse organization
GO:0050808	synapse organization