InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Klk8

Summary

InnateDB Gene

IDBG-177519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klk8

Gene Name

kallikrein related-peptidase 8

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000064023

Encoded Proteins

IDBP-177521

kallikrein related-peptidase 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129455:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer. [provided by RefSeq, Jul 2008]
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:43797577-43803822

Strand

Forward strand

Band

Transcripts

ENSMUST00000085461

ENSMUSP00000082588

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0007613	memory
GO:0008219	cell death
GO:0009611	response to wounding
GO:0031642	negative regulation of myelination
GO:0043616	keratinocyte proliferation
GO:0048681	negative regulation of axon regeneration
GO:0048812	neuron projection morphogenesis
GO:0050807	regulation of synapse organization
GO:0050808	synapse organization

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000129455

View Gene Order

ENSBTAG00000015128

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.458023

RefSeq

NM_008940 XM_006540908

OMIM

CCDS

CCDS21182

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas