InnateDB Protein
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IDBP-177529.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Kcne2
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Protein Name
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potassium voltage-gated channel, Isk-related subfamily, gene 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000048849
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InnateDB Gene
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IDBG-177527 (Kcne2)
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Protein Structure
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Function |
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KCLQT1 and elicit a voltage-independent current (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005242
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inward rectifier potassium channel activity
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GO:0005249
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voltage-gated potassium channel activity
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GO:0005251
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delayed rectifier potassium channel activity
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GO:0005515
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protein binding
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GO:0015459
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potassium channel regulator activity
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GO:0042803
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protein homodimerization activity
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GO:0044325
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ion channel binding
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GO:1902282
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voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
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Biological Process |
GO:0006811
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ion transport
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GO:0007568
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aging
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GO:0010107
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potassium ion import
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GO:0034613
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cellular protein localization
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GO:0035690
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cellular response to drug
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GO:0043586
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tongue development
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GO:0060306
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regulation of membrane repolarization
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GO:0060307
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regulation of ventricular cardiac muscle cell membrane repolarization
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GO:0071435
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potassium ion export
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GO:0071805
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potassium ion transmembrane transport
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GO:0086002
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cardiac muscle cell action potential involved in contraction
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GO:0086005
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ventricular cardiac muscle cell action potential
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GO:0086009
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membrane repolarization
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GO:0086011
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membrane repolarization during action potential
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GO:0086091
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regulation of heart rate by cardiac conduction
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GO:1901379
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regulation of potassium ion transmembrane transport
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GO:1901800
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positive regulation of proteasomal protein catabolic process
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GO:1901979
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regulation of inward rectifier potassium channel activity
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GO:1902159
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regulation of cyclic nucleotide-gated ion channel activity
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GO:1902259
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regulation of delayed rectifier potassium channel activity
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GO:2001257
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regulation of cation channel activity
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Cellular Component |
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PDB ID |
MGI:1891123
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InterPro |
IPR000369
Potassium channel, voltage-dependent, beta subunit, KCNE
IPR005425
Potassium channel, voltage-dependent, beta subunit, KCNE2
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PFAM |
PF02060
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PRINTS |
PR00168
PR01605
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D808
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PhosphoSite |
PhosphoSite-Q9D808
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
246133
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UniGene |
Mm.410006
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RefSeq |
NP_598871
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MGI ID |
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MGI Symbol |
Kcne2
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OMIM |
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CCDS |
CCDS28333
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HPRD |
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IMGT |
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EMBL |
AK008619
BC022699
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GenPept |
AAH22699
BAB25781
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