Version 5.4
Mus musculus Protein: Phkb
Summary
InnateDB Protein IDBP-177532.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phkb
Protein Name phosphorylase kinase beta
Synonyms AI463271;
Species Mus musculus
Ensembl Protein ENSMUSP00000050788
InnateDB Gene IDBG-177530 (Phkb)
Protein Structure
UniProt Annotation
Function Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 1 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004689 phosphorylase kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0005976 polysaccharide metabolic process
GO:0005977 glycogen metabolic process
GO:0006468 protein phosphorylation
Cellular Component
GO:0005886 plasma membrane
GO:0005964 phosphorylase kinase complex
Protein Structure and Domains
PDB ID MGI:97578
InterPro IPR008928 Six-hairpin glycosidase-like
IPR011613 Glycoside hydrolase family 15
PFAM PF00723
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TSH2
PhosphoSite PhosphoSite-Q7TSH2
TrEMBL Q3U6H6
UniProt Splice Variant
Entrez Gene 102093
UniGene Mm.237296
RefSeq NP_955517
MGI ID
MGI Symbol Phkb
OMIM
CCDS CCDS22501
HPRD
IMGT
EMBL AC116323 AC117185 AC122830 AK153136 BC053105
GenPept AAH53105 BAE31748

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca