InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apba3

Summary

InnateDB Protein

IDBP-177649.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apba3

Protein Name

amyloid beta (A4) precursor protein-binding, family A, member 3

Synonyms

AW208791; lin-10; Mint-3; mint3; X11gamma;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050995

InnateDB Gene

IDBG-177647 (Apba3)

Protein Structure

UniProt Annotation

Function

May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0001701	in utero embryonic development
GO:0007268	synaptic transmission
GO:0010468	regulation of gene expression
GO:0015031	protein transport
GO:0043086	negative regulation of catalytic activity