InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Runx1

Summary

InnateDB Protein

IDBP-177715.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Runx1

Protein Name

runt related transcription factor 1

Synonyms

AML1; CBF-alpha-2; Cbfa2; Pebp2a2; Pebpa2b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023673

InnateDB Gene

IDBG-177713 (Runx1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	43 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0070491	repressing transcription factor binding

Biological Process

GO:0001501	skeletal system development
GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0002318	myeloid progenitor cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007417	central nervous system development
GO:0009966	regulation of signal transduction
GO:0030099	myeloid cell differentiation
GO:0030182	neuron differentiation
GO:0030853	negative regulation of granulocyte differentiation
GO:0030854	positive regulation of granulocyte differentiation
GO:0031069	hair follicle morphogenesis
GO:0035162	embryonic hemopoiesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048266	behavioral response to pain
GO:0048666	neuron development
GO:0060216	definitive hemopoiesis
GO:0071336	regulation of hair follicle cell proliferation
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:2000872	positive regulation of progesterone secretion

Cellular Component

GO:0005604	basement membrane
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:99852

InterPro

IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
IPR008967 p53-like transcription factor, DNA-binding
IPR013524 Runt domain
IPR013711 Runx, C-terminal domain
IPR016554 Runt-related transcription factor RUNX

PFAM

PF00853
PF08504

PRINTS

PR00967

PIRSF

PIRSF009374

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt