Version 5.4
Mus musculus Gene: Runx1
Summary
InnateDB Gene IDBG-177713.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Runx1
Gene Name runt related transcription factor 1
Synonyms AML1; CBF-alpha-2; Cbfa2; Pebp2a2; Pebpa2b
Species Mus musculus
Ensembl Gene ENSMUSG00000022952
Encoded Proteins
IDBP-177715
runt related transcription factor 1
IDBP-252781
runt related transcription factor 1
IDBP-625976
runt related transcription factor 1
IDBP-789443
runt related transcription factor 1
IDBP-789445
runt related transcription factor 1
IDBP-789446
runt related transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159216:
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:92601466-92826149
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000023673 ENSMUSP00000023673
ENSMUST00000113956 ENSMUSP00000109589
ENSMUST00000168195 ENSMUSP00000131079
ENSMUST00000187242 ENSMUSP00000139819
ENSMUST00000189126
ENSMUST00000186296 ENSMUSP00000140419
ENSMUST00000189679 ENSMUSP00000140495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 43 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 80 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0070491 repressing transcription factor binding
Biological Process
GO:0001501 skeletal system development
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0002318 myeloid progenitor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007417 central nervous system development
GO:0009966 regulation of signal transduction
GO:0030099 myeloid cell differentiation
GO:0030182 neuron differentiation
GO:0030853 negative regulation of granulocyte differentiation
GO:0030854 positive regulation of granulocyte differentiation
GO:0031069 hair follicle morphogenesis
GO:0035162 embryonic hemopoiesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048266 behavioral response to pain
GO:0048666 neuron development
GO:0060216 definitive hemopoiesis
GO:0071336 regulation of hair follicle cell proliferation
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2000872 positive regulation of progesterone secretion
Cellular Component
GO:0005604 basement membrane
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159216
View Gene Order
ENSBTAG00000004742
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05221
Acute myeloid leukemia pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_21
RANKL pathway
REACTOME
KEGG
hsa05221
Acute myeloid leukemia pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.403285 Mm.4081 Mm.470227
RefSeq NM_001111021 NM_001111022 NM_001111023 NM_009821 XM_006522882
OMIM
CCDS CCDS28339 CCDS49916 CCDS49917
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca