InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim11

Summary

InnateDB Protein

IDBP-177731.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim11

Protein Name

tripartite motif-containing 11

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090749

InnateDB Gene

IDBG-177729 (Trim11)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. {ECO:0000269PubMed:12670303, ECO:0000269PubMed:18248090, ECO:0000269PubMed:18628401}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18628401}. Nucleus {ECO:0000269PubMed:18628401}. Note=In the nucleus, colocalizes with PAX6.

Disease Associations

Tissue Specificity

Expressed in embryonic central nervous system (CNS), kidney, thymus and gut.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019904	protein domain specific binding
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0032897	negative regulation of viral transcription
GO:0045087	innate immune response
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046597	negative regulation of viral entry into host cell
GO:0046598	positive regulation of viral entry into host cell
GO:0050768	negative regulation of neurogenesis
GO:0051607	defense response to virus
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:2137355

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF13639
PF14634
PF00622
PF13765
PF00097

PRINTS

PR01407

PIRSF

SMART

SM00336
SM00184
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt