InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trim11

Summary

InnateDB Gene

IDBG-177729.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim11

Gene Name

tripartite motif-containing 11

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020455

Encoded Proteins

IDBP-177731

tripartite motif-containing 11

IDBP-263743

tripartite motif-containing 11

IDBP-263745

tripartite motif-containing 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154370:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:58978093-58991458

Strand

Forward strand

Band

B1.3

Transcripts

ENSMUST00000093061	ENSMUSP00000090749
ENSMUST00000108810	ENSMUSP00000104438
ENSMUST00000108809	ENSMUSP00000104437

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019904	protein domain specific binding
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0032897	negative regulation of viral transcription
GO:0045087	innate immune response
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046597	negative regulation of viral entry into host cell
GO:0046598	positive regulation of viral entry into host cell
GO:0050768	negative regulation of neurogenesis
GO:0051607	defense response to virus
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000154370

View Gene Order

ENSBTAG00000039246

Not yet available

Pathways

NETPATH

REACTOME

REACT_236645

Class I MHC mediated antigen processing & presentation pathway

REACT_230745

Immune System pathway

REACT_199115

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_229531

Adaptive Immune System pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.399599

RefSeq

NM_001290988 NM_053168 XM_006534578 XM_006534579

OMIM

CCDS

CCDS36168 CCDS70195

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas