InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ano6

Summary

InnateDB Protein

IDBP-177786.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ano6

Protein Name

anoctamin 6

Synonyms

2900059G15Rik; AA407480; AW554778; F730003B03Rik; Tmem16f;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071770

InnateDB Gene

IDBG-177784 (Ano6)

Protein Structure

UniProt Annotation

Function

Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. {ECO:0000269PubMed:21107324, ECO:0000269PubMed:21908539, ECO:0000269PubMed:22936354, ECO:0000269PubMed:23021219}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Shows an intracellular localization. {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominant expression seen in epithelial tissues. Also found in skeletal system where it is primarily expressed in osteoblasts. {ECO:0000269PubMed:20056604, ECO:0000269PubMed:22936354}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005227	calcium activated cation channel activity
GO:0005229	intracellular calcium activated chloride channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0017128	phospholipid scramblase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0002407	dendritic cell chemotaxis
GO:0002543	activation of blood coagulation via clotting cascade
GO:0006812	cation transport
GO:0006821	chloride transport
GO:0007596	blood coagulation
GO:0017121	phospholipid scrambling
GO:0034765	regulation of ion transmembrane transport
GO:0035630	bone mineralization involved in bone maturation
GO:0044070	regulation of anion transport
GO:0061588	calcium activated phospholipid scrambling
GO:0061589	calcium activated phosphatidylserine scrambling
GO:0061590	calcium activated phosphatidylcholine scrambling
GO:0061591	calcium activated galactosylceramide scrambling
GO:0097045	phosphatidylserine exposure on blood platelet
GO:1902476	chloride transmembrane transport
GO:2000353	positive regulation of endothelial cell apoptotic process