Version 5.4
Mus musculus Gene: Ano6
Summary
InnateDB Gene IDBG-177784.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ano6
Gene Name anoctamin 6
Synonyms 2900059G15Rik; AA407480; AW554778; F730003B03Rik; Tmem16f
Species Mus musculus
Ensembl Gene ENSMUSG00000064210
Encoded Proteins
IDBP-177786
anoctamin 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25651887
[Homo sapiens] Stimulation of P2RX7 receptors activates ANO6 to enhance bacterial phagocytosis and killing by macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177119:
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:95790843-95975464
Strand Forward strand
Band E3
Transcripts
ENSMUST00000071874 ENSMUSP00000071770
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005227 calcium activated cation channel activity
GO:0005229 intracellular calcium activated chloride channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0017128 phospholipid scramblase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0002407 dendritic cell chemotaxis
GO:0002543 activation of blood coagulation via clotting cascade
GO:0006812 cation transport
GO:0006821 chloride transport
GO:0007596 blood coagulation
GO:0017121 phospholipid scrambling
GO:0034765 regulation of ion transmembrane transport
GO:0035630 bone mineralization involved in bone maturation
GO:0044070 regulation of anion transport
GO:0061588 calcium activated phospholipid scrambling
GO:0061589 calcium activated phosphatidylserine scrambling
GO:0061590 calcium activated phosphatidylcholine scrambling
GO:0061591 calcium activated galactosylceramide scrambling
GO:0097045 phosphatidylserine exposure on blood platelet
GO:1902476 chloride transmembrane transport
GO:2000353 positive regulation of endothelial cell apoptotic process
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000177119
View Gene Order
ENSBTAG00000002902
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_268398
Orphan transporters pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_267716
Orphan transporters pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q6P9J9
TrEMBL
UniProt Splice Variant
Entrez Gene 105722
UniGene Mm.38087 Mm.452138
RefSeq NM_001253813 NM_175344 XM_006520229 XM_006520230 XM_006520231 XM_006520232 XM_006520233 XM_006520234
OMIM
CCDS CCDS37184
HPRD
IMGT
MGI ID MGI:2145890
MGI Symbol Ano6
EMBL AK089300 BC060732
GenPept AAH60732 BAC40833
RNA Seq Atlas 105722

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca