InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gad1

Summary

InnateDB Protein

IDBP-177869.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gad1

Protein Name

glutamic acid decarboxylase 1

Synonyms

EP10; Gad-1; GAD25; GAD44; GAD67;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092539

InnateDB Gene

IDBG-177867 (Gad1)

Protein Structure

UniProt Annotation

Function

Catalyzes the production of GABA.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004351	glutamate decarboxylase activity
GO:0016595	glutamate binding
GO:0016829	lyase activity
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0008152	metabolic process
GO:0009449	gamma-aminobutyric acid biosynthetic process
GO:0019752	carboxylic acid metabolic process
GO:0042136	neurotransmitter biosynthetic process
GO:0042493	response to drug

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005938	cell cortex
GO:0030424	axon
GO:0043679	axon terminus
GO:0044306	neuron projection terminus
GO:0045202	synapse
GO:0048786	presynaptic active zone

Protein Structure and Domains

PDB ID

MGI:95632

InterPro

IPR000192 Aminotransferase, class V/Cysteine desulfurase
IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00266
PF01212
PF00282

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48318

PhosphoSite