InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Npffr2

Summary

InnateDB Protein

IDBP-177915.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Npffr2

Protein Name

neuropeptide FF receptor 2

Synonyms

Gpr74; HG31; NPFF2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040033

InnateDB Gene

IDBG-177913 (Npffr2)

Protein Structure

UniProt Annotation

Function

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008188	neuropeptide receptor activity
GO:0031628	opioid receptor binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0043408	regulation of MAPK cascade
GO:0045761	regulation of adenylate cyclase activity
GO:2000479	regulation of cAMP-dependent protein kinase activity

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0015629	actin cytoskeleton
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1860130

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR005395 Neuropeptide FF receptor family
IPR005397 Neuropeptide FF receptor, type 2
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01012
PR01570
PR01572

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q924H0