Homo sapiens Protein: ITGAE
Summary
InnateDB Protein IDBP-17795.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGAE
Protein Name integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
Synonyms CD103; HUMINAE;
Species Homo sapiens
Ensembl Protein ENSP00000263087
InnateDB Gene IDBG-17793 (ITGAE)
Protein Structure
UniProt Annotation
Function Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000413 Integrin alpha chain
IPR002035 von Willebrand factor, type A
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
PFAM PF00092
PF08441
PF00357
PRINTS PR01185
PIRSF
SMART SM00327
SM00191
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P38570
PhosphoSite PhosphoSite-P38570
TrEMBL
UniProt Splice Variant
Entrez Gene 3682
UniGene Hs.513867
RefSeq NP_002199
HUGO HGNC:6147
OMIM 604682
CCDS CCDS32531
HPRD 05249
IMGT
EMBL AC116914 AF168787 BC113436 BC117207 L25851
GenPept AAB59359 AAF43107 AAI13437 AAI17208