Version 5.4
Homo sapiens Gene: ITGAE
Summary
InnateDB Gene IDBG-17793.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGAE
Gene Name integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
Synonyms CD103; HUMINAE
Species Homo sapiens
Ensembl Gene ENSG00000083457
Encoded Proteins
IDBP-17795
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
IDBP-764746
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:3714628-3801243
Strand Reverse strand
Band p13.2
Transcripts
ENST00000263087 ENSP00000263087
ENST00000570415
ENST00000572121
ENST00000572179
ENST00000571185
ENST00000571937
ENST00000572433
ENST00000574026 ENSP00000467977
ENST00000570360
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005947
View Gene Order
ENSBTAG00000015264
Not yet available
Pathways
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
integrin_cs_pathway
Integrin family cell surface interactions
integrin7_pathway
AlphaE beta7 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 3682
UniGene Hs.513867
RefSeq NM_002208
HUGO HGNC:6147
OMIM 604682
CCDS CCDS32531
HPRD 05249
IMGT
EMBL
GenPept
RNA Seq Atlas 3682

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca