InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptprn2

Summary

InnateDB Protein

IDBP-178041.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptprn2

Protein Name

protein tyrosine phosphatase, receptor type, N polypeptide 2

Synonyms

4930425H11Rik; IA2beta; mKIAA0387; phogrin; Phol; PTP-NP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064046

InnateDB Gene

IDBG-178037 (Ptprn2)

Protein Structure

UniProt Annotation

Function

Implicated in development of nervous system and pancreatic endocrine cells.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Note=Autoantigen in insulin-dependent diabetes mellitus (IDDM).

Tissue Specificity

Pancreas and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0034260	negative regulation of GTPase activity
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0016021	integral component of membrane
GO:0030141	secretory granule
GO:0030658	transport vesicle membrane
GO:0043195	terminal bouton
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:107418

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR021613 Protein-tyrosine phosphatase receptor IA-2 ectodomain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF11548

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt