InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alas2

Summary

InnateDB Protein

IDBP-178063.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alas2

Protein Name

aminolevulinic acid synthase 2, erythroid

Synonyms

ALAS; Alas-2; ALAS-E; ALASE;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066040

InnateDB Gene

IDBG-178061 (Alas2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Erythroid specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003870	5-aminolevulinate synthase activity
GO:0005515	protein binding
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0001666	response to hypoxia
GO:0006778	porphyrin-containing compound metabolic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0006879	cellular iron ion homeostasis
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0030218	erythrocyte differentiation
GO:0033014	tetrapyrrole biosynthetic process
GO:0042541	hemoglobin biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:87990

InterPro

IPR000192 Aminotransferase, class V/Cysteine desulfurase
IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
IPR004839 Aminotransferase, class I/classII
IPR010961 Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase
IPR015118 5-aminolevulinate synthase presequence
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00266
PF01053
PF00155
PF09029

PRINTS

PIRSF

PIRSF001434

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08680