InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sorbs3

Summary

InnateDB Protein

IDBP-178092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sorbs3

Protein Name

sorbin and SH3 domain containing 3

Synonyms

SCAM-1; Sh3d4; SH3P3; vinexin-g;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022682

InnateDB Gene

IDBG-178090 (Sorbs3)

Protein Structure

UniProt Annotation

Function

Promotes up-regulation of actin stress fiber formation.

Subcellular Localization

Cell junction, focal adhesion. Cell junction. Cytoplasm, cytoskeleton. Note=Localized at focal adhesion sites, cell-cell junctions and cell-extracellular matrix junctions.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017166	vinculin binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0007015	actin filament organization
GO:0031589	cell-substrate adhesion
GO:0043410	positive regulation of MAPK cascade
GO:0051496	positive regulation of stress fiber assembly