Version 5.4
Mus musculus Gene: Sorbs3
Summary
InnateDB Gene IDBG-178090.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sorbs3
Gene Name sorbin and SH3 domain containing 3
Synonyms SCAM-1; Sh3d4; SH3P3; vinexin-g
Species Mus musculus
Ensembl Gene ENSMUSG00000022091
Encoded Proteins
IDBP-178092
sorbin and SH3 domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120896:
This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein\'s ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:70180468-70207637
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000022682 ENSMUSP00000022682
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0017166 vinculin binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007015 actin filament organization
GO:0031589 cell-substrate adhesion
GO:0043410 positive regulation of MAPK cascade
GO:0051496 positive regulation of stress fiber assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120896
View Gene Order
ENSBTAG00000014401
Not yet available
Pathways
NETPATH
REACTOME
REACT_235059
Smooth Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9R1Z8
TrEMBL Q8K0M3
UniProt Splice Variant
Entrez Gene 20410
UniGene Mm.5068
RefSeq NM_001271407 NM_001271408 NM_001271409 NM_011366 XM_006518737 XM_006518739 XM_006518741 XM_006518742
OMIM
CCDS CCDS27249
HPRD
IMGT
MGI ID MGI:700013
MGI Symbol Sorbs3
EMBL AB190911 AF064806 BC030933 U58889
GenPept AAC52642 AAD32303 AAH30933 BAD91315
RNA Seq Atlas 20410

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca