InnateDB Protein
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IDBP-178240.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cbln1
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Protein Name
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cerebellin 1 precursor protein
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Synonyms
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AI323299;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000034076
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InnateDB Gene
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IDBG-178238 (Cbln1)
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Protein Structure
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Function |
Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion. {ECO:0000269PubMed:16234806, ECO:0000269PubMed:17030622, ECO:0000269PubMed:17331201, ECO:0000269PubMed:20395510, ECO:0000269PubMed:21410790, ECO:0000269PubMed:23141067}.The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted. Cell junction, synapse, postsynaptic cell membrane. Note=Interaction with CBLN3 may cause partial retention in the endoplasmic reticulum.
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Disease Associations |
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Tissue Specificity |
Expressed and secreted by presynaptic neurons, such as cerebellar granule cells. Following secretion, the protein binds to GRID2 on the postsynaptic Purkinje cell membranes. Expressed at the highest level in the cerebellar cortex. High levels are also seen in the olfactory bulb, posterior part of the cerebral cortex, certain thalamic nuclei, and deep cerebellar nuclei. Low to moderate levels are detected in some hypothalamic and brainstem nuclei. In the thalamus, expressed in parafascicular nucleus neurons and other regions (at protein level). {ECO:0000269PubMed:16930405, ECO:0000269PubMed:17030622, ECO:0000269PubMed:22220752, ECO:0000269PubMed:23141067, ECO:0000269PubMed:3199194, ECO:0000269PubMed:3420533}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:88281
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InterPro |
IPR001073
Complement C1q protein
IPR008983
Tumour necrosis factor-like domain
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PFAM |
PF00386
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PRINTS |
PR00007
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PIRSF |
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SMART |
SM00110
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TIGRFAMs |
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Modification |
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SwissProt |
Q9R171
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PhosphoSite |
PhosphoSite-Q9R171
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TrEMBL |
Q80W16
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UniProt Splice Variant |
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Entrez Gene |
12404
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UniGene |
Mm.470723
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RefSeq |
NP_062600
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MGI ID |
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MGI Symbol |
Cbln1
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OMIM |
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CCDS |
CCDS22506
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HPRD |
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IMGT |
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EMBL |
AF164680
BC051956
BC055730
BC132120
BC132122
CH466525
X61448
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GenPept |
AAD47280
AAH51956
AAH55730
AAI32121
AAI32123
CAA43688
EDL11038
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