InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nasp

Summary

InnateDB Protein

IDBP-178328.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nasp

Protein Name

nuclear autoantigenic sperm protein (histone-binding)

Synonyms

5033430J04Rik; AI131596; AI317140; D4Ertd767e; Epcs32; Nasp-T;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079946

InnateDB Gene

IDBG-178322 (Nasp)

Protein Structure

UniProt Annotation

Function

Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and linker H1 histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000269PubMed:12509435, ECO:0000269PubMed:15533935, ECO:0000269PubMed:16728391}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10893414, ECO:0000269PubMed:12509435, ECO:0000269PubMed:16728391}. Nucleus {ECO:0000269PubMed:10893414, ECO:0000269PubMed:12509435, ECO:0000269PubMed:16728391}.

Disease Associations

Tissue Specificity

Isoform 1 is found in gametes, embryonic cells and transformed cells. Isoform 2 is found in dividing somatic cells (at protein level). {ECO:0000269PubMed:10893414}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042393	histone binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0001824	blastocyst development
GO:0006260	DNA replication
GO:0007049	cell cycle
GO:0008283	cell proliferation
GO:0015031	protein transport
GO:0043486	histone exchange