InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hao2

Summary

InnateDB Protein

IDBP-178364.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hao2

Protein Name

hydroxyacid oxidase 2

Synonyms

AI325478; Hao-2; Hao3; Haox3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029464

InnateDB Gene

IDBG-178362 (Hao2)

Protein Structure

UniProt Annotation

Function

Has 2-hydroxyacid oxidase activity. Most active on medium-chain substrates.

Subcellular Localization

Peroxisome.

Disease Associations

Tissue Specificity

Pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003973	(S)-2-hydroxy-acid oxidase activity
GO:0005102	receptor binding
GO:0010181	FMN binding
GO:0015930	glutamate synthase activity
GO:0016491	oxidoreductase activity
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors
GO:0052852	very-long-chain-(S)-2-hydroxy-acid oxidase activity
GO:0052853	long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
GO:0052854	medium-chain-(S)-2-hydroxy-acid oxidase activity

Biological Process

GO:0006537	glutamate biosynthetic process
GO:0018924	mandelate metabolic process
GO:0019395	fatty acid oxidation
GO:0051260	protein homooligomerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:96012

InterPro

IPR000262 FMN-dependent dehydrogenase
IPR001093 IMP dehydrogenase/GMP reductase
IPR002932 Glutamate synthase, central-C
IPR012133 Alpha-hydroxy acid dehydrogenase, FMN-dependent

PFAM

PF01070
PF00478
PF01645

PRINTS

PIRSF

PIRSF000138

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NYQ2