Version 5.4
Mus musculus Gene: Hao2
Summary
InnateDB Gene IDBG-178362.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hao2
Gene Name hydroxyacid oxidase 2
Synonyms AI325478; Hao-2; Hao3; Haox3
Species Mus musculus
Ensembl Gene ENSMUSG00000027870
Encoded Proteins
IDBP-178364
hydroxyacid oxidase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116882:
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed predominantly in liver and kidney and has the highest activity toward the substrate 2-hydroxypalmitate. Two alternatively spliced variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:98874577-98893239
Strand Reverse strand
Band F2.2
Transcripts
ENSMUST00000029464 ENSMUSP00000029464
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003973 (S)-2-hydroxy-acid oxidase activity
GO:0005102 receptor binding
GO:0010181 FMN binding
GO:0015930 glutamate synthase activity
GO:0016491 oxidoreductase activity
GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors
GO:0052852 very-long-chain-(S)-2-hydroxy-acid oxidase activity
GO:0052853 long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
GO:0052854 medium-chain-(S)-2-hydroxy-acid oxidase activity
Biological Process
GO:0006537 glutamate biosynthetic process
GO:0018924 mandelate metabolic process
GO:0019395 fatty acid oxidation
GO:0051260 protein homooligomerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116882
View Gene Order
ENSBTAG00000000123
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00630
Glyoxylate and dicarboxylate metabolism pathway
mmu04146
Peroxisome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt Q9NYQ2
TrEMBL
UniProt Splice Variant
Entrez Gene 56185
UniGene Mm.281874
RefSeq NM_019545
OMIM
CCDS CCDS17671
HPRD
IMGT
MGI ID MGI:96012
MGI Symbol Hao2
EMBL AF231918 AF272947 AJ251820 AK078908
GenPept AAF40201 AAF81795 BAC37452 CAB96380
RNA Seq Atlas 56185

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca