InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pou5f1

Summary

InnateDB Protein

IDBP-178410.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pou5f1

Protein Name

POU domain, class 5, transcription factor 1

Synonyms

NF-A3; Oct-3; Oct-3/4; Oct-4; Oct3; Oct3/4; Oct4; Otf-3; Otf-4; Otf3; Otf3-rs7; Otf3g; Otf4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025271

InnateDB Gene

IDBG-178408 (Pou5f1)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. {ECO:0000269PubMed:17496161, ECO:0000269PubMed:17525163}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00108, ECO:0000255PROSITE- ProRule:PRU00530, ECO:0000269PubMed:17496161, ECO:0000269PubMed:17525163}. Note=Expressed in a diffuse and slightly punctuate pattern.

Disease Associations

Tissue Specificity

Expressed the totipotent and pluripotent stem cells of the pregastrulation embryo. Also expressed in primordial germ cells and in the female germ line. Absent from adult tissues. {ECO:0000269PubMed:1690859, ECO:0000269PubMed:1972777}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 370 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	370 [view]
Protein-Protein	337 [view]
Protein-DNA	33 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0031625	ubiquitin protein ligase binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0070974	POU domain binding
GO:0071837	HMG box domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001710	mesodermal cell fate commitment
GO:0001711	endodermal cell fate commitment
GO:0001712	ectodermal cell fate commitment
GO:0001714	endodermal cell fate specification
GO:0001824	blastocyst development
GO:0001829	trophectodermal cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0009786	regulation of asymmetric cell division
GO:0010033	response to organic substance
GO:0019827	stem cell maintenance
GO:0030718	germ-line stem cell maintenance
GO:0032526	response to retinoic acid
GO:0034097	response to cytokine
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0045165	cell fate commitment
GO:0045596	negative regulation of cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045955	negative regulation of calcium ion-dependent exocytosis
GO:0048863	stem cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0017053	transcriptional repressor complex
GO:0044798	nuclear transcription factor complex