InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ngef

Summary

InnateDB Protein

IDBP-178473.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ngef

Protein Name

neuronal guanine nucleotide exchange factor

Synonyms

ephexin; Tims2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027477

InnateDB Gene

IDBG-178471 (Ngef)

Protein Structure

UniProt Annotation

Function

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension. {ECO:0000269PubMed:11336673, ECO:0000269PubMed:15848799, ECO:0000269PubMed:17143272}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Associated with membranes. Localizes to axonal growth cones (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain and to a lower extent in eye. {ECO:0000269PubMed:10777665}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0009987	cellular process
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043087	regulation of GTPase activity
GO:0048013	ephrin receptor signaling pathway
GO:0061002	negative regulation of dendritic spine morphogenesis