InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Akr1a1

Summary

InnateDB Protein

IDBP-178495.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Akr1a1

Protein Name

aldo-keto reductase family 1, member A4 (aldehyde reductase)

Synonyms

2610201A18Rik; Akr1a4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030455

InnateDB Gene

IDBG-178493 (Akr1a1)

Protein Structure

UniProt Annotation

Function

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10842086}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004032	alditol:NADP+ 1-oxidoreductase activity
GO:0008106	alcohol dehydrogenase (NADP+) activity
GO:0047939	L-glucuronate reductase activity

Biological Process

GO:0019853	L-ascorbic acid biosynthetic process
GO:0042840	D-glucuronate catabolic process
GO:0046185	aldehyde catabolic process
GO:0055114	oxidation-reduction process