Version 5.4
Mus musculus Gene: Akr1a1
Summary
InnateDB Gene IDBG-178493.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akr1a1
Gene Name aldo-keto reductase family 1, member A1 (aldehyde reductase)
Synonyms 2610201A18Rik; Akr1a4
Species Mus musculus
Ensembl Gene ENSMUSG00000028692
Encoded Proteins
IDBP-178495
aldo-keto reductase family 1, member A4 (aldehyde reductase)
IDBP-536736
aldo-keto reductase family 1, member A4 (aldehyde reductase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117448:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:116636510-116651680
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000030455 ENSMUSP00000030455
ENSMUST00000128010
ENSMUST00000126146
ENSMUST00000128059 ENSMUSP00000114861
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0008106 alcohol dehydrogenase (NADP+) activity
GO:0047939 L-glucuronate reductase activity
Biological Process
GO:0019853 L-ascorbic acid biosynthetic process
GO:0042840 D-glucuronate catabolic process
GO:0046185 aldehyde catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117448
View Gene Order
ENSBTAG00000000497
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00010
Glycolysis / Gluconeogenesis pathway
mmu00040
Pentose and glucuronate interconversions pathway
mmu00561
Glycerolipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B1AXW3 Q810X5
UniProt Splice Variant
Entrez Gene 58810
UniGene Mm.30085
RefSeq NM_021473
OMIM
CCDS CCDS18514
HPRD
IMGT
MGI ID MGI:1929955
MGI Symbol Akr1a1
EMBL AH012641 AL831786
GenPept AAO72144
RNA Seq Atlas 58810

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca