Version 5.4
Mus musculus Protein: Dync1i2
Summary
InnateDB Protein IDBP-178617.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dync1i2
Protein Name dynein cytoplasmic 1 intermediate chain 2
Synonyms 3110079H08Rik; AW554389; Dncic2;
Species Mus musculus
Ensembl Protein ENSMUSP00000080410
InnateDB Gene IDBG-178613 (Dync1i2)
Protein Structure
UniProt Annotation
Function Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0007018 microtubule-based movement
GO:0008152 metabolic process
Cellular Component
GO:0005813 centrosome
GO:0005868 cytoplasmic dynein complex
GO:0005874 microtubule
GO:0031982 vesicle
Protein Structure and Domains
PDB ID MGI:107750
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR025956 Cytoplasmic dynein 1 intermediate chain 1/2
PFAM PF00400
PF11540
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88487
PhosphoSite PhosphoSite-O88487
TrEMBL D6Q0F7
UniProt Splice Variant
Entrez Gene 13427
UniGene Mm.462387
RefSeq NP_034194
MGI ID
MGI Symbol Dync1i2
OMIM
CCDS CCDS16112
HPRD
IMGT
EMBL AF063231 AK088015 AK164437 AK168730 BC139374 BC139375 CH466519 GU992210
GenPept AAC33446 AAI39375 AAI39376 ADF57197 BAC40097 BAE37788 BAE40571 EDL27081

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca