InnateDB Protein
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IDBP-178712.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slc30a5
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Protein Name
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solute carrier family 30 (zinc transporter), member 5
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Synonyms
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1810010K08Rik; AF233321; ZnT-5; ZNT5; Zntl1; ZTL1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000065764
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InnateDB Gene
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IDBG-178710 (Slc30a5)
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Protein Structure
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Function |
Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP (By similarity). {ECO:0000250}.
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Subcellular Localization |
Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005385
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zinc ion transmembrane transporter activity
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GO:0008324
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cation transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1916298
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InterPro |
IPR002524
Cation efflux protein
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PFAM |
PF01545
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R4H9
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PhosphoSite |
PhosphoSite-Q8R4H9
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TrEMBL |
Q05C53
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UniProt Splice Variant |
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Entrez Gene |
69048
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UniGene |
Mm.412646
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RefSeq |
NP_075023
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MGI ID |
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MGI Symbol |
Slc30a5
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OMIM |
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CCDS |
CCDS26739
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HPRD |
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IMGT |
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EMBL |
AF461761
AK051183
AK166006
BC029033
BC029217
BC033452
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GenPept |
AAH29033
AAH29217
AAH33452
AAL96438
BAC34549
BAE38515
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