InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgd1

Summary

InnateDB Protein

IDBP-178717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgd1

Protein Name

FYVE, RhoGEF and PH domain containing 1

Synonyms

ZFYVE3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026296

InnateDB Gene

IDBG-178715 (Fgd1)

Protein Structure

UniProt Annotation

Function

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269PubMed:12913069}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12913069}. Cell projection, lamellipodium {ECO:0000269PubMed:12913069}. Cell projection, ruffle {ECO:0000269PubMed:12913069}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12913069}. Note=Associated with membrane ruffles and lamellipodia.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0031267	small GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0030036	actin cytoskeleton organization
GO:0035023	regulation of Rho protein signal transduction
GO:0043088	regulation of Cdc42 GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0046847	filopodium assembly

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

MGI:104566

InterPro

IPR000219 Dbl homology (DH) domain
IPR000306 FYVE zinc finger
IPR001849 Pleckstrin homology domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related

PFAM

PF00621
PF01363
PF00169

PRINTS

PIRSF

SMART

SM00325
SM00064
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P52734