InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc6a11

Summary

InnateDB Protein

IDBP-178739.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc6a11

Protein Name

solute carrier family 6 (neurotransmitter transporter, GABA), member 11

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032451

InnateDB Gene

IDBG-178737 (Slc6a11)

Protein Structure

UniProt Annotation

Function

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Can also transport beta-alanine and taurine.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004014	adenosylmethionine decarboxylase activity
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005332	gamma-aminobutyric acid:sodium symporter activity
GO:0042165	neurotransmitter binding

Biological Process

GO:0006836	neurotransmitter transport
GO:0007420	brain development
GO:0008295	spermidine biosynthetic process
GO:0015812	gamma-aminobutyric acid transport
GO:0042493	response to drug
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

MGI:95630

InterPro

IPR000175 Sodium:neurotransmitter symporter
IPR002982 Sodium:neurotransmitter symporter, GABA, GAT-3
IPR016067 S-adenosylmethionine decarboxylase, core

PFAM

PF00209

PRINTS

PR00176
PR01197

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P31650